We said the HSP110ΔE9 allele is dominant to HSP110WT. First part of this answer choice is consistent with our breakdown, but the second half is incorrect. Cancer-suppressing and recessive to HSP110WT.The HSP110ΔE9 allele appears to be cancer-suppressing, and there is a difference in tumor volume in the HSP110ΔE9 versus HSP110WT mice because the HSP110ΔE9 allele is dominant to HSP110WT.
This answer choice matches our breakdown of the question. Cancer-suppressing and dominant to HSP110WT.Additionally, the allele is cancer-suppressing. This answer choice is incorrect on two accounts. Cancer-promoting and recessive to HSP110WT.There is a clear difference in tumor volume in the HSP110ΔE9 versus HSP110WT mice because the HSP110ΔE9 allele is dominant to HSP110WT. However, it does mention the HSP110ΔE9 allele being dominant to HSP110WT which appears correct. If this were the case, we would see tumor volume increase relative to HSP110WT in Figure 1. Right away, this does not come across as a good answer because it says the HSP110ΔE9 allele promotes cancer. Cancer-promoting and dominant to HSP110WT.We know cancer as a disease in which the cells of a tissue undergo uncontrolled proliferation, but the HSP110ΔE9 allele appears to be cancer-suppressing. The tumor volume shown along the Y-axis as time passes is increasing much more slowly for the cells expressing HSP110ΔE9.
What biggest trend do we see? Relative to the wild type, HSP110ΔE9 slows tumor growth. We can see the effect of HSP110ΔE9 on tumorigenesis by comparing with HSP110WT. Along those same lines, we want to look at Figure 1 to start jumping into some observations about HSP110ΔE9. For example, note any trends or outliers in the experimental results, but you don’t have to memorize tumor volumes at every time interval. 1) For passages like this one, it’s always imperative to understand what is going on in the experiments, but not worry about memorizing any specific details.
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